Sy-proven AL Anlotinib biological activity amyloidosis patients with LV hypertrophy (CA) and to explore the impact of myocardial deformation changes on clinical staging and outcome in theseMyocardial Strain in Systemic Amyloidosis PatientsTable 1. AL amyloidosis related clinical features and therapy responses.All patients n = 33 Male ( ) Age (years) AL amyloidosis ( ) AL amyloidosis plus multiple myeloma ( ) Light chain type k light chain ( ) l light chain ( ) Number of organ involvements Renal ( ) Hepatic/gastrointestinal ( ) Lung ( ) 25033180 Neuropathic ( ) Soft tissues/bone ( ) Treatment for AL amyloidosis ( ) High-dose melphalan plus ASCT Oral melphalan or plus prednisone or bortezomib Lenalidomide plus Dex Cyclophosphamid/CD/CAD/CTD VCD/VTD/VMD R-CVP Various (VAD, immunotherapy, etc.) Hematological response to treatment ( ) 42 33 9 21 36 6 9 30 48 52 1.760.8 64 73 9 6 22 58 65610 64Compensated group n = 14 64 6468 57Decompensated group n = 19 53 66611 6850 50 1.560.8 57 64 7 1447 53 1.960.7 68 79 11 064 14 7 21 50 0 1426* 47* 10 21 26 10 5*P,0.05 vs. Compensated group. ASCT: autologous stem-cell transplantation; Dex: dexamethasone; CD: cyclophosphamide/dexamethasone; CAD: cyclophosphamide/ adriamycin/dexamethasone; CTD: cyclophosphamide/thalidomide/dexamethasone; VCD: velcade/cyclophosphamide/dexamethasone; VTD: velcade/thalidomide/ dexamethasone; VMD: velcade/melphalan/dexamethasone; R-CVP: rituximab plus/vincristine/prednisone; VAD: vincristine/adriamycin/dexamethasone. doi:10.1371/journal.pone.0056923.tpatients. Our hypothesis was that the evaluation of deformation changes in patients with CA is superior to the degree of hypertrophy as well as left ventricular ejection fraction (EF) for predicting prognosis in these patients.Methods Ethics StatementWritten informed consent was obtained from all patients or their guardians. The study was approved by Local Ethics Committee at the University of Wurzburg and conducted in ?accordance to the Declaration of BTZ-043 manufacturer Helsinki.Study Population and Study ProtocolAfter excluding patients with coronary artery disease, moderate to severe cardiac valve stenosis, moderate to severe hypertension, and hypertrophic cardiomyopathies unrelated to amyloidosis, 60 consecutive biopsy-proven patients with AL amyloidosis, hospitalized between January 2005 and April 2011 in the university hospitals of Wurzburg (n = 55) and Zagreb (n = 5), were screened ?for initial analysis. At least one biopsy specimen from endomyocardial tissue, bone marrow, rectum, kidney, or subcutaneous fat was positive for amyloid. The presence of amyloid was visualized by Congo red staining, producing apple-green birefringence under polarized light. The plasma cell disorder was assessed by immunohistochemical staining of the bone marrow for k and l light chains, and by serum/urine Ig and free light chain testing.Organ systemic involvement was defined by clinical and laboratory manifestations of renal, cardiac, hepatic, gastrointestinal, neuropathic, pulmonary, or soft tissue involvement according to recently published consensus criteria by specialists in cardiology and haematology [10]. Haematological response to treatment was defined as a 50 decrease in serum and urine monoclonal component [11]. The response was evaluated every 3 months by monitoring serum and urine level of monoclonal protein. Sixteen out of 60 systemic amyloidosis patients were excluded because of the lack of LV hypertrophy (LV mean thickness ,12 mm) during echocardiography examination. The remaining 44 pa.Sy-proven AL amyloidosis patients with LV hypertrophy (CA) and to explore the impact of myocardial deformation changes on clinical staging and outcome in theseMyocardial Strain in Systemic Amyloidosis PatientsTable 1. AL amyloidosis related clinical features and therapy responses.All patients n = 33 Male ( ) Age (years) AL amyloidosis ( ) AL amyloidosis plus multiple myeloma ( ) Light chain type k light chain ( ) l light chain ( ) Number of organ involvements Renal ( ) Hepatic/gastrointestinal ( ) Lung ( ) 25033180 Neuropathic ( ) Soft tissues/bone ( ) Treatment for AL amyloidosis ( ) High-dose melphalan plus ASCT Oral melphalan or plus prednisone or bortezomib Lenalidomide plus Dex Cyclophosphamid/CD/CAD/CTD VCD/VTD/VMD R-CVP Various (VAD, immunotherapy, etc.) Hematological response to treatment ( ) 42 33 9 21 36 6 9 30 48 52 1.760.8 64 73 9 6 22 58 65610 64Compensated group n = 14 64 6468 57Decompensated group n = 19 53 66611 6850 50 1.560.8 57 64 7 1447 53 1.960.7 68 79 11 064 14 7 21 50 0 1426* 47* 10 21 26 10 5*P,0.05 vs. Compensated group. ASCT: autologous stem-cell transplantation; Dex: dexamethasone; CD: cyclophosphamide/dexamethasone; CAD: cyclophosphamide/ adriamycin/dexamethasone; CTD: cyclophosphamide/thalidomide/dexamethasone; VCD: velcade/cyclophosphamide/dexamethasone; VTD: velcade/thalidomide/ dexamethasone; VMD: velcade/melphalan/dexamethasone; R-CVP: rituximab plus/vincristine/prednisone; VAD: vincristine/adriamycin/dexamethasone. doi:10.1371/journal.pone.0056923.tpatients. Our hypothesis was that the evaluation of deformation changes in patients with CA is superior to the degree of hypertrophy as well as left ventricular ejection fraction (EF) for predicting prognosis in these patients.Methods Ethics StatementWritten informed consent was obtained from all patients or their guardians. The study was approved by Local Ethics Committee at the University of Wurzburg and conducted in ?accordance to the Declaration of Helsinki.Study Population and Study ProtocolAfter excluding patients with coronary artery disease, moderate to severe cardiac valve stenosis, moderate to severe hypertension, and hypertrophic cardiomyopathies unrelated to amyloidosis, 60 consecutive biopsy-proven patients with AL amyloidosis, hospitalized between January 2005 and April 2011 in the university hospitals of Wurzburg (n = 55) and Zagreb (n = 5), were screened ?for initial analysis. At least one biopsy specimen from endomyocardial tissue, bone marrow, rectum, kidney, or subcutaneous fat was positive for amyloid. The presence of amyloid was visualized by Congo red staining, producing apple-green birefringence under polarized light. The plasma cell disorder was assessed by immunohistochemical staining of the bone marrow for k and l light chains, and by serum/urine Ig and free light chain testing.Organ systemic involvement was defined by clinical and laboratory manifestations of renal, cardiac, hepatic, gastrointestinal, neuropathic, pulmonary, or soft tissue involvement according to recently published consensus criteria by specialists in cardiology and haematology [10]. Haematological response to treatment was defined as a 50 decrease in serum and urine monoclonal component [11]. The response was evaluated every 3 months by monitoring serum and urine level of monoclonal protein. Sixteen out of 60 systemic amyloidosis patients were excluded because of the lack of LV hypertrophy (LV mean thickness ,12 mm) during echocardiography examination. The remaining 44 pa.
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