Emonstrated respectively, relative to the HRR groupsand summarized in Table 2. The AUC-ROC curve for serum CEA and Cyfra21-1 performed were in identifying LC danger for serum CEA, that discriminating LC from HRR ML-SA1 site groups better0.782, 0.797 and 0.606 in HRR groups Cyfra21-1 and IL-8. Then, we evaluated the sensitivity and specificity of serum CEA, compared with IL-8, respectively, relative to the HRR groups (Figure 4). The comparison of ROC demonstrated that serum CEA and Cyfra21-1 performed much better in identifying LC Cyfra21-1 and IL-8 levels in LC individuals in comparison with HRR groups. The sensitivity of serum threat Cyfra21-1 and compared with 58.6 and we evaluated the sensitivity and 94 and CEA,in HRR groups IL-8 have been 57.three ,IL-8. Then, 48 along with the specificity have been 98 ,specificity of serum CEA, Cyfra21-1 and CEA Cyfra21-1 and IL-8 were 890.4 pg/mL, 682.five pg/mL 76 . The reduce off values of serumIL-8 levels in LC sufferers in comparison to HRR groups. The sensitivity of serum CEA, Cyfra21-1 and IL-8 were that serum CEA and Cyfra21-1 speciand five pg/mL (Table two). According to this outcome, it appears 57.3 , 58.six and 48 as well as the had been ficity had been 98 , 94 and 76 . The reduce off values threat in high radon locations. far better diagnostic markers for early detection of LC of serum CEA Cyfra21-1 and IL-8 have been 890.4 pg/mL, 682.5 pg/mL and five pg/mL (Table two). Depending on this result, it appears that serum CEA and Cyfra21-1 were better diagnostic markers for early detection of LC threat in high radon places.Life 2021, 11,7 ofLife 2021, 11, x FOR PEER REVIEW7 ofTable two. The diagnostic sensitivity and specificity of serum CEA, Cyrfra21-1 and IL-8 in LC individuals Table two. The diagnostic sensitivity and specificity of serum CEA, Cyrfra21-1 and IL-8 in LC sufferers in comparison with HRR groups. in comparison to HRR groups. Biomarker Sensitivity Specificity AUCBiomarker Sensitivity CEA CEA 57.three Cyfra21-1 IL-8 Cyfra21-1 58.6 IL-857.3 58.6Specificity 98 9498 94AUC 0.7821 0.7821 0.7968 0.6063 0.7968 0.Figure four. ROC curves for the diagnosis of LC threat in LC patients in comparison with HRR groups. Figure 4. ROC curves for the diagnosis of LC danger in LC patients in comparison to HRR groups.four. Discussion 4. Discussion In line with the international cancer statistical evaluation, LC is among the most important wellness As outlined by the global cancer statistical evaluation, LC is one of the principal overall health probproblems worldwide, displaying the highest prices of incidence and death and being the lems worldwide,cancer amongst highest rates of incidence and death and being theRadon most common displaying the the population in Chiang Mai (Thailand) [1,two,4]. most common cancer among thecause of LC in Chiang Maismoking and the big danger thenonis the C2 Ceramide Purity seconding major population soon after tobacco (Thailand) [1,two,4]. Radon is always to seconding top causea earlier study we demonstrated that therisk to non-smokers [5smokers [5,11]. In of LC after tobacco smoking as well as the key values of indoor radon 9,11]. Within a previousChiangwe demonstrated that thehigher than the corresponding international concentration in study Mai have been significantly values of indoor radon concentration in Chiang values (39considerably higher than the35 to 219 Bq/m3 , with an typical value average Mai have been Bq/m3 ), ranging among corresponding worldwide typical values (39 Bq/m3), ranging among 35 to 219 Bq/m3, with an typical value of 57 Bq/m3 is improved of 57 Bq/m3 . It has been viewed as that the danger of LC development . It has been16 per 100that the risk of LC development is elevated by 16 per one hundred.