DBCO-PEG-NHS

Supplementary Information:
Synonyms： DBCO-PEG-SC Dibenzocycolctyne-PEG-NHS Purity： ≥95% Recommended Storage Condition： Store at -5°C,keep in dry and avoid sunlight. Uses： Protein-peptide conjugates;• Antibody-enzyme or antibody-drug conjugates;• Protein or peptide-oligonucleotide conjugates;• Surface modification . DBCO-PEG-NHS is a PEG derivative with a dibenzocyclooctyne (DBCO) functional group and an N-hydroxysuccinimide (NHS) ester moiety. The NHS ester group enables the selective coupling of the DBCO-PEG molecule to primary amines on biomolecules, such as proteins and peptides. The DBCO functional group further facilitates bioconjugation via copper-free click chemistry, specifically with molecules containing azide groups. This reaction, known as strain-promoted azide-alkyne cycloaddition (SPAAC), enables rapid, biocompatible, and specific conjugation under physiological conditions without the need for toxic catalysts.