Product Name :
USP19 polyclonal antibody
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Stable for at least 1 year after receipt when stored as recommended.
Description:
The deubiquitinylating enzyme USP19 is induced in skeletal muscle atrophy in response to numerous catabolic stimuli, including cancer, fasting, diabetes, and glucocorticoids. Loss of USP19 interferes with the growth of L6 myoblasts through its modulation of the transcription of major myofibrillar proteins.USP19 regulates cell growth, partly through indirect control of p27Kip1 degradation in the G1 phase of the cell cycle. Since a number of cancers are associated with enhanced degradation of p27Kip1, the overexpression of USP19 may also be a pathogenetic mechanism of the disordered cell growth in cancer and a potential novel therapeutic target for its treatment.513-00-8 custom synthesis In addition USP19 has been shown to be a tail anchored DUB, localised to the ER, suggesting a role in the turnover of ERAD substrates and to be targeted by the unfolded protein response.USP19 is expressed in a wide range of tissues and is localised to the cytoplasm and endoplasmic reticulum.497-30-3 custom synthesis Figure: Detection of full length USP19 and its degradation fragments in mouse testis lysate (50µg) by Western blot using USP19, pAb (1:100).PMID:20301764 Figure: Detection of full length USP19 and its degradation fragments in mouse testis lysate (50µg) by Western blot using USP19, pAb (1:100).
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| Alternative Name ZMYND9, Zinc finger MYND domain-containing protein 9 | Application WB | Formulation Liquid. In 100mM TRIS, pH 7.0 containing 100mM glycine and 0.02% sodium azide. | Host Rabbit | Immunogen Recombinant fragment of human USP19 (aa 1-129). | Recommendation Dilutions/Conditions Western Blot (1:100)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from rabbit serum. | Species Reactivity Human, Mouse, Rat | UniProt ID O94966 | Unit of Measure (UM) µl
