Table). Moderately RP54476MedChemExpress Dalfopristin exposed women less often reported having an unhealthy diet than unexposed women: adjusted prevalence ratio 0.92 (0.86; 0.98) (Table 2). No differences were found between Nutlin-3a chiral biological activity severely exposed and unexposed women. No significant interaction with age was observed (P = 0.51) (S5 Table). We also investigated the mMDS continuously. In the total population, moderately exposed women had a 0.08 point (95 CI: 0.00; 0.16) higher mMDS, compared to unexposed women (Table 3). No differences were found between severely exposed and unexposed women, and no interaction with age was found (P = 0.77) (S6 Table).PLOS ONE | DOI:10.1371/journal.pone.0156609 May 31,5 /Famine Exposure and Unhealthy Lifestyle BehaviorTable 1. Characteristics of the study population at recruitment, according to level of famine exposure, n = 7,525. Level of famine exposure Unexposed Participants Age at start of famine (Oct 1 , 1944), in years Aged 0? years during famine (childhood) Aged 10?8 years during famine (adolescent) Age at recruitment (1993?997), in years BMI, kg/m2 Waist, cm Level of educationstModerately exposed 2838 (38 ) 8.8 (5.4) 1601 (56 ) 1237 (44 ) 59.5 (5.5) 26.2 (4.0) 84.4 (9.9) 627 (22 ) 1355 (48 ) 402 (14 ) 454 (16 ) 1246 (44 ) 997 (35 ) 595 (21 ) 218 (8 ) 742 (26 ) 728 (26 ) 1150 (41 ) 17 (0 ) 1562 (55 ) 682 (24 ) 577 (20 ) 1790 (411) 4.1 (1.5) 979 (35 )Severely exposed 1237 (16 ) 9.1 (5.1) 662 (54 ) 575 (46 ) 59.7 (5.2) 26.2 (4.2) 84.7 (10.4) 320 (26 ) 617 (50 ) 152 (12 ) 148 (12 ) 503 (41 ) 457 (37 ) 277 (22 ) 112 (9 ) 288 (23 ) 339 (27 ) 498 (40 ) 12 (1 ) 749 (61 ) 228 (18 ) 248 (20 ) 1756 (428) 4.0 (1.5) 474 (38 )N ( ) Mean (SD) N ( ) N( ) Mean (SD) Mean (SD) Mean (SD) N ( ) Very low Low Middle High3450 (46 ) 8.0 (5.3) 2122 (62 ) 1328 (38 ) 58.8 (5.4) 26.0 (3.9) 83.5 (9.8) 820 (24 ) 1691 (49 ) 461 (13 ) 478 (14 ) 1667 (48 ) 1121 (32 ) 662 (19 ) 206 (6 ) 951 (28 ) 875 (25 ) 1418 (41 ) 15 (0 ) 1917 (56 ) 790 (23 ) 728 (21 ) 1800 (420) 4.0 (1.5) 1300 (38 )Smoking statusN ( )Never Former CurrentPhysical activity levelN ( )Inactive Moderately inactive Moderately active ActiveAlcohol consumptionN ( )Never Light (0? g/day) Moderate (5?5 g/day) Heavy ( 15 g/day)Energy intake in kcal/day mMDS, excluding alcohol Unhealthy diet (mMDS<4) doi:10.1371/journal.pone.0156609.tMean (SD) Mean (SD) N ( )Famine exposure was associated with physical inactivity. Both moderately exposed and severely exposed women were more often physically inactive than unexposed women, adjusted prevalence ratio 1.18 (0.99; 1.42) and 1.32 (1.06; 1.64), respectively (P for trend = 0.08) (Table 2). The dose-dependent relation was more pronounced in the older age category (P for trend = 0.001) (S7 Table).DiscussionIn our study, women who reported severe exposure to famine during their youth were more often smokers and smoked more later in life compared to women who were not exposed. Exposed women were also more often physically inactive. Associations were dose-dependent: stronger exposure to famine was associated with higher prevalence of smoking and physical inactivity. No interactions with age were found. We found no associations of famine exposure with alcohol consumption and no dose-dependent relations with diet. These results are in accordance with our hypothesis that famine exposure during important developmental periods, such as childhood and adolescence, may relate to an unhealthier lifestyle later in life. However, famine exposure was not associated with alcohol consumption.Table). Moderately exposed women less often reported having an unhealthy diet than unexposed women: adjusted prevalence ratio 0.92 (0.86; 0.98) (Table 2). No differences were found between severely exposed and unexposed women. No significant interaction with age was observed (P = 0.51) (S5 Table). We also investigated the mMDS continuously. In the total population, moderately exposed women had a 0.08 point (95 CI: 0.00; 0.16) higher mMDS, compared to unexposed women (Table 3). No differences were found between severely exposed and unexposed women, and no interaction with age was found (P = 0.77) (S6 Table).PLOS ONE | DOI:10.1371/journal.pone.0156609 May 31,5 /Famine Exposure and Unhealthy Lifestyle BehaviorTable 1. Characteristics of the study population at recruitment, according to level of famine exposure, n = 7,525. Level of famine exposure Unexposed Participants Age at start of famine (Oct 1 , 1944), in years Aged 0? years during famine (childhood) Aged 10?8 years during famine (adolescent) Age at recruitment (1993?997), in years BMI, kg/m2 Waist, cm Level of educationstModerately exposed 2838 (38 ) 8.8 (5.4) 1601 (56 ) 1237 (44 ) 59.5 (5.5) 26.2 (4.0) 84.4 (9.9) 627 (22 ) 1355 (48 ) 402 (14 ) 454 (16 ) 1246 (44 ) 997 (35 ) 595 (21 ) 218 (8 ) 742 (26 ) 728 (26 ) 1150 (41 ) 17 (0 ) 1562 (55 ) 682 (24 ) 577 (20 ) 1790 (411) 4.1 (1.5) 979 (35 )Severely exposed 1237 (16 ) 9.1 (5.1) 662 (54 ) 575 (46 ) 59.7 (5.2) 26.2 (4.2) 84.7 (10.4) 320 (26 ) 617 (50 ) 152 (12 ) 148 (12 ) 503 (41 ) 457 (37 ) 277 (22 ) 112 (9 ) 288 (23 ) 339 (27 ) 498 (40 ) 12 (1 ) 749 (61 ) 228 (18 ) 248 (20 ) 1756 (428) 4.0 (1.5) 474 (38 )N ( ) Mean (SD) N ( ) N( ) Mean (SD) Mean (SD) Mean (SD) N ( ) Very low Low Middle High3450 (46 ) 8.0 (5.3) 2122 (62 ) 1328 (38 ) 58.8 (5.4) 26.0 (3.9) 83.5 (9.8) 820 (24 ) 1691 (49 ) 461 (13 ) 478 (14 ) 1667 (48 ) 1121 (32 ) 662 (19 ) 206 (6 ) 951 (28 ) 875 (25 ) 1418 (41 ) 15 (0 ) 1917 (56 ) 790 (23 ) 728 (21 ) 1800 (420) 4.0 (1.5) 1300 (38 )Smoking statusN ( )Never Former CurrentPhysical activity levelN ( )Inactive Moderately inactive Moderately active ActiveAlcohol consumptionN ( )Never Light (0? g/day) Moderate (5?5 g/day) Heavy ( 15 g/day)Energy intake in kcal/day mMDS, excluding alcohol Unhealthy diet (mMDS<4) doi:10.1371/journal.pone.0156609.tMean (SD) Mean (SD) N ( )Famine exposure was associated with physical inactivity. Both moderately exposed and severely exposed women were more often physically inactive than unexposed women, adjusted prevalence ratio 1.18 (0.99; 1.42) and 1.32 (1.06; 1.64), respectively (P for trend = 0.08) (Table 2). The dose-dependent relation was more pronounced in the older age category (P for trend = 0.001) (S7 Table).DiscussionIn our study, women who reported severe exposure to famine during their youth were more often smokers and smoked more later in life compared to women who were not exposed. Exposed women were also more often physically inactive. Associations were dose-dependent: stronger exposure to famine was associated with higher prevalence of smoking and physical inactivity. No interactions with age were found. We found no associations of famine exposure with alcohol consumption and no dose-dependent relations with diet. These results are in accordance with our hypothesis that famine exposure during important developmental periods, such as childhood and adolescence, may relate to an unhealthier lifestyle later in life. However, famine exposure was not associated with alcohol consumption.
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