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Zhang et al. Parasites Vectors (2015)eight:37 DOI ten.1186/s13071-015-0650-RESEARCHOpen AccessAn association of Aquaporin-4 with all the immunoregulation of liver pathology in mice infected with Schistosoma japonicumWeiwei Zhang1, Jifeng Zhu1, Xian Song1, Zhipeng Xu1, Xue Xue2, Xiaojun Chen1, Xiaowei Yang1, Yong Li1, Xiaoxiao Dong1, Sha Zhou1, Wei Li1, Yingying Qian3, Feng Liu1 and Chuan Su1*AbstractBackground: CXCR6 MedChemExpress Schistosomiasis is really a chronic parasitic illness that impacts about 200 million people today. In Schistosomiasis japonica and mansoni, parasite eggs have been trapped in host liver and stimulated the CD4+T cell responses to regulate the formation with the granulomas. Subsequently, excessive granulomatous response in some heavily, and/or repeatedly infected people could lead to chronic liver fibrosis and circulatory impairment. Therefore, elucidation of the mechanisms of these responses is not going to only offer more information and facts to better comprehend the mechanisms of your immunoregulation in schistosomiasis, but in addition enable to style new therapies to handle granuloma-associated immunopathology. The function of aquaporin-4 (AQP4) in water transport has been extensively investigated within the central nervous technique (CNS). Lately, research have show.
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