Product Name :
4-ArmPEG-SS
Purity :
≥95%
CAS NO. :
Synonyms:
4-ArmPEG-Succinimidyl Succinate ester
Storage:
Store at -5°C,keep in dry and avoid sunlight.
Formula:
Classification :
Multi-arm PEGs > NHS ester PEG
Molecular Weight:
20000
Supplementary Information:
Synonyms： 4-ArmPEG-Succinimidyl Succinate ester Purity： ≥95% Recommended Storage Condition： Store at -5°C,keep in dry and avoid sunlight. Uses： Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. 4-ArmPEG succinimidyl succinate (4-arm PEG-SS) is a high-quality multi-arm PEG derivative with succinimidyl succinate at each terminal of the four arms connected to one pentaerythritol core. It can be crosslinked into degradable PEG hydrogels, which can be used in medical devices and regenerative medicine, and are especially of interest for controlled release of drugs, for 2D and 3D cell culture, and for wound sealing and healing. 4-arm PEG-SS is available with molecular weights of 2K, 5K, 10K, 20K Da. Other MW may be available by custom synthesis.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
HDAC3 Antibody
Phospho-ERK1/2 (Thr202/Thr185) Antibody
DM4 Antibody (YA3387): Ravtansine (DM4) is a maytansinoid, a chemical derivative of maytansine being investigated as the cytotoxic payload of a number of antibody-drug conjugates (ADCs). Microtubules are dynamic cytoskeletal polymers that switch stochastically between states of growing and shortening, called “dynamic instability”. They function in the precise segregation of chromosomes during cell division, transport of cellular cargos, and positioning and movement of intracellular organelles. Inhibition of microtubule function leads to cell cycle arrest and cell death. Microtubule-targeted drugs including the Vinca alkaloids, taxanes, and epothilones suppress the dynamic instability of microtubules, induce mitotic arrest, inhibit cell proliferation and induce apoptosis. The anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function. The maytansinoid emtansine (DM1), for example, binds at the ends of microtubules and thereby suppress their dynamic instability. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death. DM4 can be used in the preparation of antibody drug conjugate. Although S-methyl DM1 and S-methyl DM4 inhibited microtubule assembly more weakly than maytansine, they suppressed dynamic instability more strongly than maytansine. Like vinblastine, the maytansinoids potently suppress microtubule dynamic instability by binding to a small number of high affinity sites, most likely at microtubule ends. Thus, the maytansine derivatives that result from cellular metabolism of the antibody conjugates are themselves potent microtubule poisons, interacting with microtubules as effectively as or more effectively than the parent molecule.
